Cardiorespiratory synchronism in estimation of regulatory and adaptive organism status

Pokrovskii V.M., Polischuk L.V.

Journal of Integrative Neuroscience. - 2016. - V.15. - 1. - P. 1935.


Regulatory Adaptive Status in Assessment of Efficacy of Pharmacotherapy and Prognostication of Complications in Functional Class III Chronic Heart Failure

Tregubov V.G., Kanorskiy S.G., Pokrovskii V.M.

Kardiologija. - 2016. - V. 56. - 1.- P. 12-17. (in Russian).


Objective: to elucidate significance of regulatory adaptive status (RAS) for assessment of effectiveness of medical treatment and prediction of cardiovascular complications in functional class (FC) III congestive heart failure (CHF). Material and methods. We included into this study 100 patients with hypertensive disease (HD) or ischemic heart disease (IHD) and FC III CHF with compromised systolic left ventricular (LV) function. All patients were randomized into two groups. In addition to complex background therapy (quinapril, torasemide, spironolactone) patients of group 1 (n = 56, age 57.521.7 years) were given metoprolol succinate (59.1 12.1 mg/day) and patients of group 2 (n = 44, age 57.1 21.4 years) - ivabradine (12.1 4.6 mg/day). Examination at baseline and after 6 months included cardiorespiratory synchronism test (in order to quantitatively define RAS), echocardiography, treadmill test, six minutes walk test. Cardiovascular complications (CVC) were registered during 12 months of study treatment. Results. Both schemes of complex therapy equally improved structural and functional state of the myocardium, increased tolerance to physical exercise, reduced neurohumoral hyperactivation. Positive impact on RAS was more pronounced in ivabradine group. Clinical efficacy of therapy as well as number of hospitalizations because of CHF decompensation, ischemic strokes, and cardiovascular deaths did not differ substantially between groups. Initially low or unsatisfactory RAS was associated with higher incidence of CVC while initial unsatisfactory RAS was associated with elevated risk of sudden death. Conclusion. The data obtained reflect independent value of determination of RAS for assessment of efficacy of pharmacotherapy and prognosis of CVC in patients with FCIII CHF.
Keywords: chronic heart failure, cardiovascular complications, cardiorespiratory synchronism, regulatory adaptive status.

Detection of Flashing Areas Attributed to the Frog Cardiac Function in the Vagosympathetic Trunk Placed into a High Frequency Electric Field

Pokrovskii V.M., Abushkevich V.G., Perova Y.Y., Perova M.Y., Pokhotko A.G. and Ardelyan A.N.

Doklady Biological Sciences. 2016. - Vol. 468. - . 12.


Objective: in a high frequency electric field, two flashing areas were observed during each contraction of the heart in the vagosympathetic trunk of a paralyzed frog with an intact brain. One area with a higher diameter was moving along the nerve from the heart at a speed of 16.6 0.2 m/s. It was identified as afferent. Another area with a smaller diameter was spreading along the nerve towards the venous sinus of the frog heart at a speed of 5.6 0.3 m/s, and it was efferent.