Cardiorespiratory synchronism in estimation of regulatory and adaptive organism status
Pokrovskii V.M., Polischuk L.V.Journal of Integrative Neuroscience. - 2016. - V.15. - №1. - P. 19–35.
DOI: http://dx.doi.org/10.1142/S0219635216500060
To the 95th anniversary of Vladimir Mikhailovich Pokrovsky, the creator of ideas about the leading role of the brain level in the hierarchical system of cardiac rhythmogenesis in the whole organism
Cherednik I.L., Kashina Y.V., Polischuk S.V., Ardelyan A.N.Integrative Physiology. - 2024. - V. 5. - № 1.- P. 6-11. (in Russian).
DOI: https://intphysiology.ru/index.php/main/article/view/298
Objective: The volley stimulation of efferent structures of the vagus nerves proposed by V.M. Pokrovsky was an adequate experimental model for studying the nervous effects on the heart in the body. Stimulation of the sympathetic cardiac nerves revealed their modulating effect on the phenomenon of synchronization of vagal and cardiac rhythms. The proposed method of obtaining cardio-respiratory synchrony in all people who are able to control breathing to the beat of the stimulator with a certain frequency has shown that in this case, signals are formed in the medulla oblongata in the efferent nuclei of the vagus nerves, coming to the sinoatrial node, and the heart begins to contract with the frequency of these signals. The central generator provides adaptive responses of the heart under natural conditions by suppressing the intracardiac generator that supports the pumping function of the heart when the central nervous system is in a state of deep inhibition. In the experiment, a short-term cardiac arrest was obtained in dogs with a bilateral one-time blockade of vagus nerve excitation – a pre-automatic pause. The transition from central rhythm guidance to the automation of the sinoatrial node was accompanied by a decrease in heart rate, which indicated the manifestation of the principle of the gradient of automation. When simulating a decrease in the degree of dominance of the central level of rhythmogenesis in dogs, an increase in electrocardiographic manifestations of sinus node weakness syndrome was recorded, while a decrease in the cross-section of the focus of initial excitation in the sinoatrial region of the heart was recorded.